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KMID : 0377619890540060377
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Korean Jungang Medical Journal
1989 Volume.54 No. 6 p.377 ~ p.383
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In Vitro Susceptibility of Cryptococcus neoformans to Amphotericin B, Nystatin, 5-fluorocytosine, Ketoconazole, Mconazole, and Rifampicin Alone and in Combination
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Abstract
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In vitro antifungal activities of ketonazole, miconazole, amphotericin B, nystatin, 5-fluorocytosine and rifampicin in combined with ketoconazole/miconazole are determined against 4 strains of Cryptococcus enoformans.
The minimum inhibitory concentrations of ketoconazole, miconazole, amphotericin B, nystatin, 5-fluorocytosine and rifampicin for tested strains were ranged from 0.047pg m1-1 - 0.094 pg ml-´, 0.78 pg m1 1 - 1.50 pg ml-´, 0.39 pg m1´1 - 1.56 pg ml-1, 40.0 pg ml-1 - 50.0 pg ml-1, 0.25 pg ml-1 - 6.25 pg ml-1 and > 100.0 pg ml-1.
The growth curve experiment with on strain of Qyptococcus neoformans. WCM-1 demonstrated that the combination of ketoconazole/miconazole produced a decrease in number of colony forming unit of <2 logs in 24 hours of observation.
On the basis of theses studies, it is concluded that ketoconazole/miconzaole are synergistic against Cryptococcus neoformans under experimental conditions.
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